Packaging RNA drugs into extracellular vesicles
Monique A. J. van Eijndhoven, S. Rubina Baglio & D. Michiel Pegtel
Published:-
Nature Biomedical Engineering
14 January 2020
Source:- Nature.com
At a glance:-
Monique A. J. van Eijndhoven, S. Rubina Baglio & D. Michiel Pegtel
Published:-
Nature Biomedical Engineering
14 January 2020
Source:- Nature.com
At a glance:-
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| DNA structure - 3D |
Packaging RNA drugs into extracellular vesicles. The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.
What do extracellular vesicles do?
Extracellular vesicle are known to facilitate intercellular communication in diverse cellular processes such as immune responses and coagulation.
What is Exosomal RNA?
Exosomes are nano-sized extracellular vesicles, of endosomal origin. They are released by cells and found in many body fluids, including plasma. Exosomes contain proteins, microRNAs , and messenger RNAs that can be transferred between cells.
What is an intracellular vesicle?
Sometimes cells need to transport small amounts of materials, like specific molecules. And The process of surrounding small quantities of materials, either from outside the cell or from some organelle is called pinocytosis. The small sacs that carry such material are called vesicles.
There are essentially four types of vesicles used by cells. They are vacuoles, lysosomes, transport vesicles, and secretory vesicles. Vacuoles are vesicles that contain mostly water.
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