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The Gattermann–Koch reaction, named after the German chemists Ludwig Gattermann and julius Arnold koch is a variant of the Gattermann reaction in which carbon monoxide (CO) is used instead of hydrogen cyanide.
Unlike the Gattermann reaction, this reaction is not applicable to phenol and phenol ether substrates. Additionally, when zinc chloride is used as the catalyst, the presence of traces of copper(1) chloride co-catalyst is often necessary.
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