📚📚 PDF file for the application of Pictet Spengler Reaction, 👉👉 Click Here
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At a glance:- The Pictet Spengler Reaction is a Chemical reaction where a beta-arylethylamine that can undergo condensation reaction with an aldehyde or ketone followed by ring closure.
The reaction was first discovered by Am Pictet and Theodor Spengler in 1911.
Mechanism :- This reaction mechanism occurs by initial formation of an iminium ion followed by an electrophilic addition at the 3- position. in which the nucleophilicity of indole is increased. And it gives a spirocycle. After the formation of spirocycle the migration of the higher migratory aptitude group that can migrates, and after deprotonation takes place to give final product.
🎦 For Complete information about the Synthesis of Isoquinoline, 👉 Click Here
At a glance:- The Pictet Spengler Reaction is a Chemical reaction where a beta-arylethylamine that can undergo condensation reaction with an aldehyde or ketone followed by ring closure.
The reaction was first discovered by Am Pictet and Theodor Spengler in 1911.
Mechanism :- This reaction mechanism occurs by initial formation of an iminium ion followed by an electrophilic addition at the 3- position. in which the nucleophilicity of indole is increased. And it gives a spirocycle. After the formation of spirocycle the migration of the higher migratory aptitude group that can migrates, and after deprotonation takes place to give final product.
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