👉👉 PDF || Shapiro Reaction //application are collection from research papers
At a glance:-
The Shapiro reaction is an organic reaction in which a ketone or aldehyde is converted to an alkene through the formation of an intermediate hydrazone in the presence of 2 equivalent of organolithium reagent.
The reaction was first discovered by Robert H. Shapiro in 1967.
This reaction is similar to the Bamford-Stevens reaction, which also involves the basic decomposition of tosyl hydrazones.
Organolithium reagents:- they are organometallic compounds having carbon-carbon bonds. Ther are important reagents in organic synthesis.and they are frequently used to transfer the organic group or the lithium atom to the substrates in various synthetic steps, like nucleophilic addition or simple deprotonation.
Hydrazone:- hydrazones are a class of Organic compounds with the structure R
1R
2C=NNH
2. They are actually related to the ketones and aldehyde by the replacement of the oxygen with the NNH2 functional group.
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