📚👉👉 PDF of Mannich Reaction with Application
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At a glance:- the Mannich Reaction is an organic reaction which consists of an amino alkylation of an acidic proton placed next to a carbonyl functional group by formaldehyde and a primary amine or a secondary amine or ammonia. And the final product is a beta-amino-carbonyl compound also known as a Mannich base.
The reaction named after the chemist Carl Mannich.
Mannich Base:- it is a beta-amino-ketone, which is formed by the reaction of an amine, formaldehyde (or aldehyde) and a carbon acid. The Mannich base is an end product of the Mannich Reaction, which undergo nucleophilic Addition Reaction of a non-enolizable aldehyde and any primary or secondary amine, and finally it produce resonance stabilized imine (iminium ion or imine salt)
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