IIT JAM UGC CSIR NET GATE CHEMISTRY

 

👉👉 PDF || Shapiro Reaction //application are collection from research papers

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Shapiro reaction, a special types of reaction which is a very important for synthesis analysis of organic chemistry.


    At a glance:- 
   Shapiro reaction, it is an organic reaction in which a ketone or aldehyde is converted to an Alkene through an intermediate hydrazone derivative in presence of 2 equivalents of organolithium reagents.
   
     This reaction was discovered by Robert H. Shapiro in 1967.

    Actually, this reaction is very similar to Bamford Stevens Reaction. The Shapiro reaction is a variation on the Bamford Stevens Reaction, is the base induced reaction of tosylhydrazones to afford alkenes.

     Hydrazone:- hydrazones are a class of Organic compounds with the structure R
1R
2C=NNH
2.  They are actually related to the ketones and aldehyde by the replacement of the oxygen with the NNH2 functional group.


Organolithium reagents:- they are organometallic compounds having carbon-carbon bonds. Ther are important reagents in organic synthesis.and they are frequently used to transfer the organic group or the lithium atom to the substrates in various synthetic steps, like nucleophilic addition or simple deprotonation.