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The Blanc chloromethylation or the Blanc reaction is a chemical reaction of aromatic rings with formaldehyde and hydrogen chloride catalyzed by zinc chloride or other Lewis acid to form chloromethyl arenes.
The reaction was discovered by Gustave Louis Blanc (1872-1927) in 1923.
The reaction is performed with care as, like most chloromethylation reactions, it produces highly carcinogenic bis(chloromethyl) ether as a side product.
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The Blanc chloromethylation or the Blanc reaction is a chemical reaction of aromatic rings with formaldehyde and hydrogen chloride catalyzed by zinc chloride or other Lewis acid to form chloromethyl arenes.
The reaction was discovered by Gustave Louis Blanc (1872-1927) in 1923.
The reaction is performed with care as, like most chloromethylation reactions, it produces highly carcinogenic bis(chloromethyl) ether as a side product.
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